3. Summary of outcomes in published studies of binocular treatment for amblyopia.
|
Treatment adherence % |
Visual acuity gain amblyopic eye in logMAR (SD) | Visual acuity % change in amblyopic eye * | Stereoacuity gain | Recurrence | |
| Hess 2010a; Hess 2010b | ‐ | 0.26 | Not specified | “significant” | Not specified |
| Hess 2012 | ‐ | 0.19 (0.17) | Not specified | 6/10 improved | Nil at 1 to 2 months (in 4/10) |
| Knox 2012 | All | 0.09 | 22% | 7/14 (small squint), 4/7 significant | Not specified |
| To 2011 | All | 0.16 (0.18) | Not specified (fellow eye acuity not available) | Trend of improvement | Not specified |
| Li 2014 | 34/45 (76%) | 0.08 (0.01) | Not specified (not individual acuities, also in supp. material) | 5/50, not significant | Nil at 3 months |
| Kelly 2016 | 82 to 100% | ||||
| Gao 2018 | 64% in treatment group | 0.06 (0.12) active group | Not specified | 0.23 (0.76) log seconds of arc in active group; no significant change | Not specified |
| Sauvan 2019 | 16/17 participants – 9 hours 1/17 participant – 7.5 hours |
0.08 in non‐patched group | Not specified | Trend of improvement in both groups; no statistically significant improvement | Not specified |
| Birch 2020 | 103% in binocular group | 0.15 | Not specified | No significant improvement reported | Not specified |
| Vedamurthy 2015a | All | 0.14 (0.01) in dichoptic game group | 28% (2%) | 0.18 (0.05) log arc second improvement | 0.12 (0.02) in dichoptic game group at 8 week follow‐up |
| Vedamurthy 2015b | Not stated | 0.14 | Not specified | ||
| Waddingham 2006 | – | 0.27 | 42% | – | Not specified |
| Herbison 2013 | 88.5% | 0.18 (0.143) | 32.3% | Not measured | 0.055 at 10 weeks (in 6/9) |
| Herbison 2016 | > 90% (specifics not given) | 0.06 to 0.10 (mean 0.08) | Not specified | No significant improvement | Not specified |
| Bossi 2017 | Anisometropia – 87% Strabismus – between 84% and 90% |
0.27 (0.22) | not reported | Anisometropia – 6/7, significant mean gain of 165 seconds of arc Strabismus – not reported |
Unclear, as participants went onto conventional treatments after BBV |
SD: standard deviation
* calculated as (AEs‐AEe)/(AEs‐FEe), where AEs and AEe are respectively visual acuity values in amblyopic eye at entry (best‐corrected visual acuity) and exit, FEe is the acuity in the fellow eye at entry (baseline)