Figure 6.

CD8⁺ T cells and CXCL10 are necessary for antitumor immunity induced by the triple therapy. (A) Schematic illustration of neutralization assays. Mice received one of five treatments on the indicated days: vehicle, triple therapy, triple therapy with an anti-CD8 neutralizing antibody, triple therapy with an anti-CXCL10 neutralizing antibody, and/or triple therapy with both the anti-CD8 and anti-CXCL10 neutralizing antibodies. (B) Mice (n=8/group) were inoculated with Lewis cells and given treatments as described in figure part A. The volumes of the subcutaneously transplanted tumors were recorded every 3 days, and the data on the 25th day were statistically analyzed (mean±SEM); p<0.05 was considered statistically significant). (C) Kaplan-Meier survival curves of mice bearing tumors in different treatment groups (n=8/group, Gehan-Breslow-Wilcoxon test).