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. 2022 Jan 24;8:797890. doi: 10.3389/fmed.2021.797890

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Copyright © 2022 Wang, Wang, Wang, Chen, Qu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Funnel plots for RCTs reported Melasma Area and Severity Index (MASI) outcome measures. (A) Funnel plot for placebo-controlled trials; (B) funnel plot for active-controlled trials.