Table 5.

Previous CRRT QI initiatives

Study	Setting	Sample size	KPI(s) studied	Intervention	Outcomes
Griffin et al14	Single centre Adult Medical/surgical Nephrology prescription	837 CRRT treatment sessions	Delivered dose	Stakeholder engagement Modification to EMR Training of ICU nurses Standardisation of protocol Improved documentation Modification of order sets Result dissemination	Increased in treatments achieving dose (66.3% vs 33.3 %, p<0.001) Decline in underdose treatments (11.7% vs 20.7%, p<0.001) Decline in overdosed treatments (22% vs 46%, p<0.001)
Mottes et al15	Single centre Paediatric Newborn, cardiac and paediatric Nephrology prescription	184 patients 2090 patient-days	Filter life Unplanned filter changes Prescribed effluent dose Delivered vs prescribed effluent dose Fluid balance	Development of CRRT quality dashboard Provided targeted provider-based CRRT education	Mean filter life increase from 50 hours to 56 hours Unplanned filter change from 33% to 15% Mean delivered dose increased from 2400 mL/hour/1.73 m2 to 2845 mL/hour/1.73 m2 Delivered time increased from 81.1% to 92.7% Increase in achievement of daily desired fluid balance from 69.2% to 83.3%
Ruiz et al16	Single centre Adult Medical/surgical Nephrology prescription	1185 patients 7420 patient-days	CRRT modality Anticoagulation Delivered dose Delivered/prescribed dose Filter life CRRT access alarms	Assembly of multidisciplinary team Standardisation of CRRT protocol Improvement of CRRT charting Report of CRRT QI metrics Education to clinicians and ICU nurses	Increase in CVVHDF use (92.4%–100%, p<0.001) Increase in RCA use (23.1% to 39.5%, p<0.001) Improved filter life (26–31.2 hour, p=0.02) Decrease in access alarms (2.95–1.68 per day, p=0.02)

CRRT, continuous renal replacement therapy; CVVHDF, continuous veno-venous HemoDiaFiltration; EMR, electronic medical record; ICU, intensive care unit; KPI, key performance indicator; QI, quality improvement; RCA, regional citrate anticoagulation.