FIGURE 2.

Latent bioreactive unnatural amino acids (Uaas) that have been genetically encoded into proteins to covalently target different natural amino acid residues. A representative reaction is shown in the box for each category. (a) Latent bioreactive Uaas targeting Cys. (b) Latent bioreactive Uaas targeting Lys. (c) Latent bioreactive Uaas capable of targeting multiple residues. (d) Photoactivatable bioreactive Uaas reacting with specific residues in proximity