Table 2.

Summary of trial scenarios explored

Parameter	Values considered
Accrual	Constant rate of 16 per week (required accrual)
	Constant rate of 5 per week (slow accrual)
	Ramp-up (slow initially, increasing over course of study)
Time to outcome	Uniform between 48 and 72 weeks
Control response	0.1
Treatment response	0.05, 0.06, 0.07, 0.08, 0.09, 0.10
Superiority threshold	0.95, 0.955, 0.96, 0.965, 0.97
Success threshold	1, 0.975, 0.95, 0.925, 0.9, 0.8
Futility threshold	0, 0.025, 0.05, 0.075, 0.1, 0.2