Table 2.
Summary information of the selected biomarker models (original measurements)
| Model | AIC | BIC | R2, unadjusted | R2, adjusted | AUC, 95% CI | LRT x2 | P value | |
|---|---|---|---|---|---|---|---|---|
| IP-MS for Aβ42/40 | ||||||||
| All participants | AG | 124.2 | 143.6 | 40.7% | 37.5% | 86.5% (79.7, 93.4) | 53.3 | < 0.0001* |
| CU | A | 62.6 | 76.7 | 33.5% | 25.9% | 82.3% (68.5, 96.1) | 16.7 | < 0.001* |
| CI | AGP | 59.2 | 77.0 | 58.7% | 52.9% | 93.5% (87.5, 99.5) | 43.5 | < 0.0001* |
| Simoa for Aβ42/40 | ||||||||
| All participants | G | 145.5 | 159.4 | 22.2% | 19.4% | 77.5% (68.9, 86.1) | 28.0 | < 0.0001* |
| CU | G | 71.9 | 81.4 | 11.0% | 3.1% | 72.8% (58.1, 87.6) | 5.4 | 0.04 |
| CI | GP | 71.7 | 85.0 | 42.2% | 37.6% | 87.1% (78.4, 95.9) | 32.4 | < 0.01* |
| Demographic | ||||||||
| All participants | – | 155.6 | 166.7 | 12.7% | 10.5% | 70.7% (61.3, 80.0) | – | – |
| CU | – | 74.0 | 81.7 | 2.4% | − 4.0% | 58.1% (41.9, 74.3) | – | – |
| CI | – | 78.9 | 87.8 | 27.8% | 24.5% | 81.3% (71.0, 91.5) | – | – |
Abbreviations: AIC Akaike information criterion, AUC area under the curve, BIC Bayesian information criterion, CU cognitively unimpaired, CI mild cognitive impairment, LRT likelihood ratio test
*P value of the likelihood ratio test comparing the selected model with the demographic model on the respective sample group