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. Author manuscript; available in PMC: 2022 Feb 7.
Published in final edited form as: J Anxiety Disord. 2021 Oct 26;84:102490. doi: 10.1016/j.janxdis.2021.102490

Table 2.

Within-group effects separated by treatment type, domain, and time point.

Treatment Domain Time k ES I2 kimp ESadj FSN
Trauma PTSD post 17 1.11 [0.86, 1.35] 85.37 [73.66, 93.62] 4 0.93 [0.65, 1.21] 3223
Trauma SUD post 16 0.82 [0.47, 1.16] 93.55 [88.77, 97.77] 0 0.82 [0.47, 1.16] 1376
Trauma PTSD FU 15 1.10 [0.81, 1.39] 87.49 [77.34, 94.85] 0 1.10 [0.81, 1.39] 2305
Trauma SUD FU 15 0.97 [0.62, 1.33] 92.98 [87.45, 97.18] 0 0.97 [0.62, 1.33] 2009
Non-trauma PTSD post 14 0.65 [0.45, 0.84] 79.67 [62.03, 93.21] 0 0.65 [0.45, 0.84] 1178
Non-trauma SUD post 13 0.44 [0.29, 0.59] 72.47 [44.35, 89.02] 5 0.55 [0.41, 0.70] 709
Non-trauma PTSD FU 12 0.76 [0.53, 0.99] 78.82 [55.06, 91.35] 0 0.76 [0.53, 0.99] 934
Non-trauma SUD FU 12 0.43 [0.20, 0.67] 86.36 [72.03, 95.30] 1 0.48 [0.24, 0.72] 479
Manual SUD PTSD post 13 0.85 [0.58, 1.11] 79.26 [56.96, 91.99] 2 0.76 [0.50, 1.02] 800
Manual SUD SUD post 13 0.87 [0.41, 1.33] 94.70 [89.48, 98.46] 0 0.87 [0.41, 1.33] 704
Manual SUD PTSD FU 11 1.01 [0.70, 1.31] 75.30 [45.91, 92.13] 0 1.01 [0.70, 1.31] 628
Manual SUD SUD FU 11 0.80 [0.43, 1.18] 87.61 [73.58, 96.32] 0 0.80 [0.43, 1.18] 469
SUD TAU PTSD post 10 0.58 [0.30, 0.86] 85.71 [68.45, 96.28] 1 0.65 [0.35, 0.94] 449
SUD TAU SUD post 8 0.30 [0.16, 0.45] 54.15 [26.95, 97.93] 0 0.30 [0.16, 0.45] 108
SUD TAU PTSD FU 8 0.79 [0.54, 1.05] 77.46 [47.09, 94.21] 0 0.79 [0.54, 1.05] 481
SUD TAU SUD FU 8 0.52 [0.16, 0.88] 91.73 [79.59, 98.25] 0 0.52 [0.16, 0.88] 164
No tx PTSD post 5 0.49 [0.27, 0.71] 41.91 [0.00, 92.12] 0 0.49 [0.27, 0.71] 58
No tx SUD post 5 0.61 [0.29, 0.92] 75.46 [28.67, 97.13] 0 0.61 [0.29, 0.92] 108
No tx PTSD FU 1 1.04 [0.65, 1.43] NA NA NA 10
No tx SUD FU 1 1.29 [0.92, 1.66] NA NA NA 16

Note: k = number of treatment or control arms contributing to effect size estimate; ES = effect size in Hedges’ g units; I2 = heterogeneity; kimp = number of studies imputed to account for funnel plot asymmetry; ESadj = trim-and-fill adjusted effect size; SUD = substance use disorder symptoms; No tx = no treatment control; Trauma = trauma-focused treatment; Manual SUD = manualized SUD treatment; Integ non-trauma = integrated non-trauma-focused treatment; SUD TAU = SUD treatment-as-usual; FU = follow-up; NA = not available due to insufficient studies.