Table 3.
Factors associated with new hepatic decompensation
| Covariate | AOR (95% CI) | p-value |
|---|---|---|
|
| ||
|
| ||
| MOUD | 0.53 (0.28, 1.02) | 0.059 |
|
| ||
|
| ||
| Demographics | ||
|
| ||
| Age (per year) | 1.01 (0.98, 1.04) | 0.472 |
|
| ||
| BMI* | 1.01 (0.96, 1.06) | 0.678 |
|
| ||
| Race/Ethnicity (vs. Non-Hispanic White) | ||
| Non-Hispanic Black | 0.38 (0.22, 0.66) | <0.001 |
| Hispanic | 0.60 (0.29, 1.24) | 0.165 |
| Other race/ethnicity | 1.28 (0.54, 3.02) | 0.581 |
|
| ||
| Female | 3.86 (1.65, 9.04) | 0.002 |
|
| ||
| Marital status (vs. married) | ||
| Single | 1.01 (0.58, 1.76) | 0.964 |
| Divorced/widowed | 0.90 (0.58, 1.40) | 0.639 |
|
| ||
| Homeless | 0.64 (0.29, 1.42) | 0.271 |
|
| ||
|
| ||
| Liver Disease Factors | ||
|
| ||
| Hepatitis C virus | 0.82 (0.49, 1.38) | 0.456 |
|
| ||
| Hepatocellular carcinoma | 3.27 (1.08, 9.93) | 0.036 |
|
| ||
| MELD (per point) | 1.17 (1.12, 1.22) | <0.001 |
|
| ||
| Prior hepatitis C treatment | 0.63 (0.16, 2.51) | 0.512 |
|
| ||
|
| ||
| Substance Use Disorders | ||
|
| ||
| Nicotine use disorder | 0.82 (0.55, 1.22) | 0.323 |
|
| ||
| Alcohol use disorder | 2.09 (1.38, 3.18) | 0.001 |
|
| ||
| Other substance use disorders | 0.52 (0.30, 0.90) | 0.020 |
|
| ||
|
| ||
| Other Comorbidities | ||
|
| ||
| Pain related diagnoses | 0.99 (0.59, 1.66) | 0.970 |
|
| ||
| Opioid prescription | 0.65 (0.41, 1.01) | 0.054 |
|
| ||
| Mood disorders | 0.98 (0.66, 1.47) | 0.926 |
|
| ||
| Anxiety disorders | 0.81 (0.44, 1.52) | 0.521 |
|
| ||
| Schizophrenia | 1.16 (0.48, 2.83) | 0.742 |
|
| ||
| Post-traumatic stress disorder | 0.72 (0.43, 1.19) | 0.202 |
|
| ||
| Charlson Comorbidity Index (per point) | 0.75 (0.61, 0.91) | 0.005 |
*
MOUD=Medication treatment for opioid use disorder; BMI=body mass index; MELD=model for end-stage liver disease; AOR=adjusted odds ratio; CI=confidence interval