Table 4.

Spearman’s correlation coefficients between clinical characteristic and cortical and medullary volumes obtained by manual or AI-based approaches from the test sets combining all three sites.

N=1612 kidney donors	Cortical volume						Medullary volume
	Manual		Automated				Manual		Automated
Characteristic	rs	P value	rs	P value	P value		rs	P value	rs	P value	P value
Age, years	-0.220	<0.001	-0.246	<0.001	0.002		0.032	0.20	0.087	<0.001	< 0.001
Male	0.529	<0.001	0.517	<0.001	0.11		0.196	<0.001	0.188	<0.001	0.62
Donor’s height, cm	0.519	<0.001	0.511	<0.001	0.28		0.310	<0.001	0.230	<0.001	< 0.001
BMI, kg/m2	0.429	<0.001	0.378	<0.001	< 0.001		0.151	<0.001	0.221	<0.001	< 0.001
Measured GFR (ml/min)*	0.568	<0.001	0.560	<0.001	0.31		0.325	<0.001	0.336	<0.001	0.51
Measured GFR (ml/min/1.73m2)*	0.256	<0.001	0.273	<0.001	0.06		0.170	<0.001	0.155	<0.001	0.39
Estimated GFR (ml/min/1.73m2)¥	0.276	<0.001	0.309	<0.001	< 0.001		0.062	0.01	-0.020	0.43	< 0.001
Family history of ESRD†	0.124	<0.001	0.119	0.02	0.60		0.022	0.42	0.033	0.23	0.54
Hypertension	-0.037	0.14	-0.055	0.03	0.04		0.032	0.20	0.049	0.05	0.30
Uric acid, mg/dlⱡ	0.356	<0.001	0.340	<0.001	0.05		0.034	0.18	0.054	0.03	0.22
24hr Albumin‡	0.130	<0.001	0.108	0.003	0.09		0.087	0.02	0.094	0.01	0.77
Glomerular volume**	0.253	<0.001	0.207	<0.001	< 0.001		-0.058	0.06	0.000	0.99	0.004
Mean tubular area**	0.124	0.002	0.100	0.001	0.03		0.024	0.44	0.023	0.46	0.96
% Globally sclerotic glomeruli**	-0.071	0.02	-0.079	0.01	0.46		0.010	0.74	-0.009	0.78	0.34

^*Measured GFR available in 1361 donors.

^¥Estimated GFR available in 1604 donors.

^†Family history of ESRD available in 1339 donors.

^ⱡUric acid available in 1581 donors.

^‡24hr Albumin available in 747 donors.

^**Biopsy measures available in 1066 kidney donors.