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. Author manuscript; available in PMC: 2022 Apr 7.
Published in final edited form as: Nature. 2021 Apr 7;592(7855):611–615. doi: 10.1038/s41586-021-03440-3

Extended Data Figure 5. Distribution of rpoB mutations detected via next-generation sequencing.

Extended Data Figure 5.

DNA from ϕNM1γ6- or rifampicin-resistant staphylococci with different genetic backgrounds was extracted and subjected to NGS. Mutations that localized to either of the two clusters known to contain amino acid substitutions that confer rifampicin resistance (cluster I: Gly462 – Gly489; cluster II: Pro515 – Leu530) were counted. The % of the total mutations in these clusters is shown for different nucleotides within codons. Different data markers indicate were used to indicate different mutations. Numerical values of data points are provided in Supplementary Data File 2.