SARS-CoV-2 responsive CD8+ T cells assigned to IFNλ4 haplotype. (A) Bar chart showing whether participants responded to the investigated epitopes or not, n = 201. (B) CD8+ T cell response shown as the cumulative number of SARS-CoV-2 epitopes targeted by the responsive participants, n = 106. (C) Distribution of the cumulative CD8+ T cell responses in participants, n = 105. Ten percent of the participants had no detectable CD8+ T cell epitope response, and are not shown on the graph, but were included in statistical tests. Error bars show median and interquartile range. Statistical comparison by Mann–Whitney U test. ns = P > 0.05.