Table I.
Global rank hierarchy for the primary endpoint
| Item (from Randomization to day 4 for primary outcome) | Points |
|---|---|
| Death | 7 |
| Transfer to ICU for invasive ventilation | 6 |
| Transfer to ICU for other indication | 5 |
| Non-fatal MACE (Any of the following - MI, Stroke, Acute HF, new onset Afib) | 4 |
| Length of stay > 4 days | 3 |
| Development of acute kidney injury (>40% decline in eGFR or doubling of serum Cr) | 2 |
| Urgent intravenous treatment for high blood pressure/hypertensive crisis | 2 |
| >30% increase in baseline high sensitivity troponin | 1 |
| >30% increase in baseline BNP | 1 |
| Increase in baseline CRP >30% | 1 |
| Lymphocyte count drop >30% | 1 |
Afib, atrial fibrillation; BNP, brain natriuretic peptide; CRP, c-reactive protein; eGFR, estimated glomerular filtration rate calculated by the Modification of Diet in Renal Disease Study (MDRD) equation; ICU, intensive care unit; MACE, major adverse cardiac event; MI, myocardial infarction.