FIGURE 1.

The role of astrocytes providing a supportive role to neurons has been investigated heavily over the past 30 years. What we know now in the context of glucagon‐like peptide‐1 (GLP‐1) signalling is that first, astrocytes could theoretically help facilitate the transport of GLP‐1 across the blood–brain barrier, due to the internalization of the receptor when bound (1). GLP‐1 could modulate synaptic signalling indirectly by regulating astrocytic glutamate transporters GLT‐1 and GLAST (2) or through the release of gliotransmitters (3). GLP‐1R, glucagon‐like peptide‐1 receptor; NTS, nucleus tractus solitarius. Abbreviations, Lac, lactate; Gln, glutamine; Glu, glutamate; Ser, serine