FIGURE 3.

Comparing the effects of the dual agonist DA4‐JC with those of liraglutide side by side in the APP/PS1 model of Alzheimer's disease (AD). (a) Acquisition times for water maze training. The dual agonist improved learning times better than liraglutide. (b) Probe test percentage of target quadrant swim times. In this recall test, DA4‐JC was superior in memory consolidation and recall than liraglutide. Sample swimming tracks are shown below. (c) Quantification of beta‐amyloid plaque loads in the neocortex. DA4‐JC was more effective in reducing the amyloid load compared with liraglutide sample micrographs are shown: A = WT; B = APP/PS1 Sal; C = APP/PS1 lira; D = APP/PS1 DA4‐JC. Scale bar = 50 μm. (d) Quantification of pro‐inflammatory cytokines in the brain. DA4‐JC was more effective in reducing the chronic inflammation response. *P < .05; Sample bands are shown. Adapted from (Maskery et al., 2020)