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Actions of GLP‐1 within pancreatic alpha‐, beta‐ and delta‐cells. In beta‐cells, GLP‐1 binding to its receptor (GLP‐1R) triggers intracellular signalling cascades that positively influence insulin synthesis and secretion as well as beta‐cell proliferation and survival. The direct and indirect effects, mediated through the delta‐cell, of GLP‐1 receptor (GLP‐1R) activation on inhibition of alpha‐cell derived glucagon is also considered
