. 2021 Nov 4;179(4):600–624. doi: 10.1111/bph.15682

TABLE 2.

Physiological requirement of GLP‐1 receptor in the brain

Genetic marker	Body weight	Lean mass	EE	Fat mass	Food intake	GTT	ITT	References
*Glp‐1r* ^−/−								Scrocchi et al., ¹⁹⁹⁶; Scrocchi & Drucker, ¹⁹⁹⁸; Hansotia et al., ²⁰⁰⁷; Ayala et al., ²⁰¹⁰
Chow (Purina 5001; Research Diets 10% kcal from fat)
Male	↔ Up to 16 months	N/A	N/A	N/A	↔ and ↑ ( Hansotia et al., ²⁰⁰⁷ )	Impairment that subsides with age	N/A
Female	↔ Up to 6 months; Δ at 11/16 months	N/A	N/A	N/A	↔	Impairment that persists with age	N/A
HFD (Research Diets D12451; BioServ F3282)
Male	Protected from weight gain (D12451 @ 9–12 weeks age); ↔ F3282 @ 3 weeks age)	↓	N/A	↔	↔ and ↑ ( Hansotia et al., ²⁰⁰⁷ )	Impaired	N/A
Female	Protected from weight gain (F3282 @ 3 weeks age and D12451 @ 12 weeks age)	↓	N/A	↓	N/A	Impaired	N/A
Nestin‐Cre (JAX #3771); GLP‐1 receptor lox/lox								Sisley et al., ²⁰¹⁴
Chow (Harlan Teklad no. 7012)	↔	↔	N/A	↔	↔ (4 hr & 24 hr); however, separate cohorts saw ↑	Trend toward impairment	N/A
High Fat Diet (D12331)	↔	↔	N/A	↔	↔ (4 hr, 24 hr, & 7 days)	↔	N/A
Vgat‐iCre, GLP‐1 receptor lox/lox								Adams et al., ²⁰¹⁸
Standard chow
Male	↔	N/A	N/A	N/A	↔	N/A	N/A
Female	↔	N/A	N/A	N/A	↔	N/A	N/A
HFD (D12451); male only	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Vglut‐iCre, GLP‐1 receptor lox/lox								Adams et al., ²⁰¹⁸
Standard chow
Male	↔	N/A	N/A	N/A	↔	N/A	N/A
Female	↔	N/A	N/A	N/A	↔	N/A	N/A
HFD (D12451); male only	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Phox2b‐Cre (JAX #016223); GLP‐1 receptor lox/lox								Sisley et al., ²⁰¹⁴
Chow (Harlan Teklad no. 7012)	↔	↔	N/A	↔	↔ (4 hr & 24 hr)	Trend toward impairment	N/A
HFD (D12331)	↔	↔	N/A	↔	↔ (4 hr, 24 hr, & 7 days)	Trend toward impairment
Nkx2.1‐Cre (JAX #8661); GLP‐1 receptor lox/lox								Burmeister et al., ²⁰¹⁷
Chow (Harlan Teklad #2016)	↔	↔	↑ (48 hr)	↔	↑	↔	N/A
HFD (D12492)	↓	↔	↑ (48 hr)	↓	↔	Trend toward impairment	N/A
POMC‐Cre (JAX #5965); GLP‐1 receptor lox/lox								Burmeister et al., ²⁰¹⁷
Chow (Harlan Teklad #2016)	↔	↔	↔ (48 hr)	↔	↔	↔	N/A
HFD (D12492)	↑	↔	↔ (48 hr)	↔	↔	↔	N/A
Sim1‐Cre (JAX #6395); GLP‐1 receptor lox/lox								Burmeister et al., ²⁰¹⁷ Ghosal et al., ²⁰¹⁷
Chow (Harlan Teklad #2016)	↔	↔	↓ (48 hr)	↔	↔	Trend toward improvement	N/A
HFD (D12492)	Δ	↔	↔ (48 hr)	↔	↔	Trend toward improvement
PVH ‐ AAV‐Cre; GLP‐1 receptor lox/lox								Liu et al., ²⁰¹⁷
Standard chow	↑	N/A	↔	N/A	↑	N/A	Impaired
HFD	N/A	N/A	N/A	N/A	N/A	N/A	N/A
PVH lesion								Secher et al., ²⁰¹⁴
Chow (no. 1324, Altromin, Brogaarden)	↑	N/A	N/A	N/A	N/A	N/A	N/A
HFD	N/A	N/A	N/A	N/A	N/A	N/A	N/A
PpgGLP1‐NTSKO								Cheng et al., ²⁰²⁰
Chow (Purina Lab Diet, 5001)	↔	↔	N/A	↔	↔	N/A	N/A
HCD (Research Diets D12492)	N/A	N/A	N/A	N/A	N/A	N/A	N/A
PpgLepRbKO
Chow (Purina Lab Diet, 5001)	↔	↔	N/A	↔	↔	N/A	N/A
HCD (Research Diets D12492)	N/A	N/A	N/A	N/A	N/A	N/A	N/A

Note: ↑/↓ statistically significant response; Δ/∇ non‐significant trend; ↔ equivalent to control/ wild type.

Abbreviations: DIO, diet‐induced obese mice; EE, energy expenditure; HFD/HCD, high fat/high caloric diet; NTS, nucleus tractus solitarius; PVN, paraventricular hypothalamic nucleus.