Table 2. Summary of changes in mRNA content following a single session of high-intensity interval exercise (HIIE), measured in nine participants.
| Gene name | Time-point with highest or lowest fold change | Maximal fold change relative to baseline; Geometric mean (GSD) | 95% CI for fold change | p value | Xiao value | q value | Adj p value |
|---|---|---|---|---|---|---|---|
| PGC-1α | 3 h | 3.2 (1.8) | [2.0–5.0] | 0.0005 | 3.04 × 10−6 | 0.0110 | 0.0052 |
| PGC-1α4 | 3 h | 4.5 (2.3) | [2.3–8.5] | 0.0005 | 7.35 × 10−8 | 0.0110 | 0.0312 |
| PPARα | 3 h | 4.1 (1.5) | [3.0–5.6] | 0.0003 | 3.88 × 10−7 | 0.0110 | 0.0251 |
| CPT1A | 3 h | 2.9 (2.8) | [1.3–6.3] | 0.0503 | 0.0108 | 0.1614 | 0.0159 |
| PDK4 | 9 h | 7.4 (14) | [1.0–56.2] | 0.0315 | 0.0002 | 0.1242 | 0.1944 |
| NRF1 | 24 h | 2.5 (1.5) | [1.8–3.3] | <0.0001 | 5.66 × 10−6 | 0.0069 | 0.0072 |
| CD36 | 24 h | 0.1 (2.4) | [0.2–0.4] | 0.0106 | 0.0001 | 0.0563 | 0.1223 |
| TFEB | 24 h | 0.6 (1.5) | [0.4–0.8] | 0.0167 | 0.0500 | 0.0768 | 0.0222 |
| UCP3 | 24 h | 2.4 (4.4) | [0.8–7.4] | 0.0400 | 0.0179 | 0.1380 | 0.3903 |
| p53 | 48 h | 2.3 (1.5) | [1.4–3.8] | 0.0078 | 0.0394 | 0.0454 | 0.1058 |
| PPARγ | 48 h | 1.8 (2.6) | [0.7–1.7] | 0.0147 | 0.0409 | 0.0700 | 0.5395 |
| GLUT4 | 72 h | 0.3 (3.7) | [0.1–1.0] | 0.0004 | 3.15 × 10−7 | 0.0110 | 0.0072 |
Note:
The time-point with maximal fold changes, the geometric mean for maximal fold change with geometric standard deviation (GSD), the 95% Confidence Interval (CI), the p value determined by the Mann-Whitney test, the Xiao value determined by a novel posteriori information fusion scheme (Deshmukh et al., 2021; Xiao et al., 2014), the q value determined by a Benjamini-Hochberg false discovery rate (FDR) of <5%, and the adjusted p value (Adj p value) determined by one-way ANOVA with Dunnett test, are reported for each target gene.