. Author manuscript; available in PMC: 2022 Feb 7.

Published in final edited form as: J Steroid Biochem Mol Biol. 2020 Nov 30;206:105791. doi: 10.1016/j.jsbmb.2020.105791

Table 2.

Top 5 canonical pathways (Z score >2, p<0.05) of DHT induced transcriptomic profiles in PDX tumors of TN1 and TN2.

TN1				TN2

Ingenuity Canonical Pathways	z-score	p-value	Overlap Ratio	Ingenuity Canonical Pathways	z-score	p-value	Overlap Ratio

Rho-GDI Signaling	3.441	1.22E-03	0.138 (22/159)	Aryl Hydrocarbon Receptor Signaling	−2.212	2.69E-07	0.157 (22/140)
Rho-GTPases Signaling	−3.674	1.73E-03	0.125 (27/216)	IL-1 Mediated RXR Inhibition	−2.121	6.92E-07	0.127 (28/221)
Actin Cytoskeleton Signaling	−3.30	7.93E-03	0.119 (18/185)	Planar Cell Polarity Signaling	2.121	8.19E-03	0.123 (8/65)
Corticotropin Releasing Hormone Signaling	−2.714	6.12E-03	0.152 (14/92)	Wnt/GSK-3β Signaling	2.236	5.62E-03	0.091 (7/396)
Glutamate Receptor Signaling	−2	3.00E-03	0.128 (18/141)	Wnt/Ca+ pathway	2.449	4.43E-03	0.103 (6/58)