Skip to main content
. Author manuscript; available in PMC: 2022 Jul 5.
Published in final edited form as: Nat Chem. 2022 Jan 5;14(1):94–99. doi: 10.1038/s41557-021-00834-8

Table 2 |.

Scope of decarboxylative cross-coupling with sulfonamide nucleophiles.

graphic file with name nihms-1751283-t0003.jpg

0.20 mmol scale isolation conditions: Cu(OTf)2 (2.5 equiv.), Na3PO4 (3.0 equiv.), sulfonamide (3.0 equiv.), carboxylic acid (1.0 equiv.), CH2Cl2 (0.10 M), and i-PrCN (5.5 equiv.) are added to a 1.5-dram reaction vial equipped with a stir bar in a glovebox. The vial is irradiated by two 34 W blue LEDs at a distance of 10 cm.

a

The 1.2:1 ratio refers to the trisubstited:1,1-disubstituted olefin product distribution as determined by 1H NMR of the crude reaction mixture.

b

Diastereomers were not detected in NMR analysis.