FIG. 11.

Elevated zero maze (EZM) and light dark (L/D) escape testing of cohort 3. Amyloid precursor protein/presenilin 1 (APP/PS1) transgenic (Tg) mice were exposed to blast (n = 16) or sham (n = 16) conditions. Non-transgenic (non-Tg) littermate controls (n = 16) were exposed to sham conditions. Mice were subjected to blast or sham conditions beginning at 20 weeks of age and received three blast exposures per week for eight weeks. The times for behavioral testing are shown in Figure 8 and Table 1. For the EZM (A), time in motion (Move Time), mean speed, distance moved (Move Distance), open arm entries, time spent in the open arms, and the latency to cross into the second open arm (Cross Arm Latency) are shown. In the L/D escape task (B), the latency to reach the light center as well as total time spent on the light side and time spent in the light center are shown. Error bars indicate the standard error of the mean. Overall group differences were compared using a one-way analysis of variance (ANOVA). Asterisks indicate significant differences between groups after a significant (p < 0.05) one-way ANOVA (*p < 0.05, **p < 0.01, Fisher least significant difference).