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. 2021 Nov 2;38(22):3146–3173. doi: 10.1089/neu.2021.0184

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Copyright 2021, Mary Ann Liebert, Inc., publishers

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FIG. 4. — Novel object recognition (NOR) testing of cohort 1. Blast-exposed (n = 7) and sham-exposed (n = 8) amyloid precursor protein/presenilin 1 (APP/PS1) transgenic (Tg) mice from cohort 1 were tested in novel object recognition (NOR) and novel object localization (NOL) tasks. Panel (A) shows time spent exploring the objects (OB1 and OB2) during the NOR training session as well as exploration of the previously presented familiar object (FO) compared with the novel object (NO) when presented 1 h (short-term memory, STM) or 24 h (long-term memory, LTM) later. Panels (B) and (C) show the discrimination index (B) and total time spent exploring the objects (C) during the indicated NOR sessions. Panel (D) shows time spent exploring the objects (OB1 and OB2) during the NOL training session as well as exploration of the previously presented objects in their familiar location (FL) compared with a novel location (NL) when presented 1 h later (STM). Asterisks indicate values significantly different between groups (*p < 0.05, ***p < 0.001, unpaired t tests).