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. 2022 Jan 24;14:819440. doi: 10.3389/fnmol.2021.819440

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Copyright © 2022 Zhu, Fan, Zhao, Li, Cai, Wang, Liang, Lu, Kang, Luo, Tao, Li, Huang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PYGB overexpression in the medial prefrontal cortex decreases susceptibility to depression. (A) Timeline of AAV injection, behavioral tests, and immunohistochemistry. (B) Immunofluorescence staining to identify the astrocyte-specific localization of exogenous PYGB in mice. Scale bar = 20 μm (n = 10). (C) Western blot and quantification of PYGB and P-PYGB protein levels (n = 3). (D) Glycogen level and GP activity in astrocytic KI-Pygb mouse models (n = 7). (E) Depression-like behaviors assessed by social interaction and tail suspension (n = 8). *p < 0.05. AAV, adeno associated virus; PYGB, glycogen phosphorylase; CSDS, chronic social defeat stress mouse models; KI-Pygb, Pygb-knockin mouse models.