Table 2.
RBC Storage Time and Clinical Characteristics: Relative Risk of Delirium/Coma within 3 days of RBC Transfusion
| Characteristic | Univariate Analyses | |||||
|---|---|---|---|---|---|---|
| N | Primary Outcome N (%) | Relative Risk | LCL | UCL | P-value | |
| Age of blood | ||||||
| Short-storage RBCs | 69 | 55 (79.7) | 1.14 | 0.94 | 1.37 | 0.184 |
| Standard-issue RBCs | 77 | 54 (70.1) | Ref. | |||
| Patients Age (Days)* | 146 | 0.996 | 0.99 | 1.002 | 0.2108 | |
| PELOD-2 on randomization* | 146 | 1.08 | 1.02 | 1.15 | 0.0118 | |
| Opiates pre-transfusion | ||||||
| Yes | 98 | 86 (87.8) | 1.83 | 1.35 | 2.48 | <.0001 |
| No | 48 | 23 (47.9) | Ref. | |||
| Benzodiazepines pre-transfusion | ||||||
| Yes | 74 | 69 (93.2) | 1.68 | 1.35 | 2.08 | <.0001 |
| No | 72 | 40 (55.6) | Ref. | |||
| Cognitive status pre-transfusion** | ||||||
| Delirium/Coma | 88 | 87 (98.9) | 2.6 | 1.82 | 3.71 | <.0001 |
| Delirium-Free/Coma-Free | 50 | 19 (38.0) | Ref. | |||
*
Relative Risk was calculated per 100 days of increase in age, and per 1-unit increase in PELOD-2 score, respectively.
**
Cognitive status prior to transfusion was missing for eight subjects
[LCL: lower confidence level; UCL: upper confidence level; PELOD-2: Pediatric Logistic Organ Dysfunction-2 score (scores range from 0–33, with higher score reflecting greater severity of MODS prior to red blood cell transfusion)]