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Epigenetic control of the HPG axis during pubertal development. a Schematic representation of the HPG axis. The main organs and hormones involved and their role in pubertal development are shown. b Epigenetic control of genes of the HPG axis that mediate their repression in the prepubertal period are summarized and schematized. c Activation of these genes during the subsequent pubertal period (created in Biorender).
