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Frequency of T cell LAG-3 surface expression. LAG-3+ frequency in: (A) CD4 T cells, (B) regulatory CD4 T cells (CD25+, CD127int), (C) conventional (non-Treg), (D) CD8 T cells, (E) naïve CD8 T cells (CD45RA+CD45RO-), and (F) memory CD8 T cells (CD45RA-CD45RO+) from HC (n = 69), T1D (n = 104), and RRMS (n = 121) subjects. Lines shown are median, and p values are shown after a one-way ANOVA. Results are shown from 25 independent experiments.
