Table 2.
The Natural Products and Traditional Chinese Medicine Extracts of p38MAPK
| Authors (Years) | Samples | Extracts | Regulate | Pathways |
|---|---|---|---|---|
| Ren et al (2018)79 | ATDC5 cells | Piperine | miR-127, MyD88 | NF-κB, p38MAPK |
| Fan et al (2019)80 | ATDC5 cells | Astragalus polysaccharide (APS) | miR-92a, KLF4 axis | NF-κB, p38MAPK |
| Jin et al (2018)81 | ATDC5 cells | Resveratrol (RSV) | miR-146b | NF-κB, p38MAPK |
| Li et al (2019)82 | ATDC5 cells | Tetramethylpyrazine (TMP) | MyD88 | NF-κB, p38MAPK |
| Feng et al (2020)83 | OA patients’ Cartilage | Salvianolic acid A (SAA) | ↑Collagen II, Aggrecan. ↓MMP1, MMP13, ADAMTS-5 |
NF-κB, p38MAPK |
| Li et al (2021)84 | KOA model mice | Wang-Bi Tablet (WBT) | ↑glycosaminoglycans ↓IL-6 |
NF-κB, p38MAPK |