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. Author manuscript; available in PMC: 2022 Jul 13.
Published in final edited form as: Nat Cell Biol. 2022 Jan 13;24(1):24–34. doi: 10.1038/s41556-021-00821-8

Extended Data Fig. 6. Viral replication in apical supernatants of reconstructed human nasal epithelia cultures and bodywheight of Hamsters throughout course of SARS-CoV-2 Infection.

Extended Data Fig. 6

a-c, Calu-3 cells expressing sgRNAs knocking down genes essential for interferon signal transduction assayed for transcript levels of sgRNA targets relative to ACTB by qPCR. mRNA levels are fraction of control sgRNA. Error is the standard deviation of three biological replicates.

A, Apical supernatants of either infected or mock-infected nasal epithelia treated with ABBV-744 at the indicated concentrations or not treated (NT) were isolated and assayed for SARS-CoV-2 N RNA content. Average of four biological quadruplicates are shown with error bars representing the standard deviation. b, Hamsters were weighed over the course of SARS-CoV-2 infection and weights were plotted as a percent of bodyweight on the day of infection. Inset, zoom in on body weight percent between 85 and 110 percent.