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. 2022 Jan 24;2:784448. doi: 10.3389/froh.2021.784448

Figure 8.

Figure 8

Acute P. gingivalis infection induces dysbiosis in mice fed a Western diet. Results of 16S rRNA gene sequencing of the fecal microbiota collected 1 day after the final P. gingivalis infection. (A) Inverse Simpson index measuring alpha diversity. Groups with different letters (a, b) are significantly different. (B) Linear discriminant analysis (LDA) effect size (LEfSe) analysis of the predicted taxonomy of P. gingivalis vs. vehicle-treated mice fed a WD during acute infection. LDA > 2.0, α < 0.05. Green indicates increased abundance while red indicates reduced abundance in response to P. gingivalis. (C) Predicted pathways expected to be differentially abundant when comparing the inferred cecal metagenome enrichment of P. gingivalis-infected, WD-fed mice and vehicle-treated, WD-fed mice. No significant differences were observed between P. gingivalis-infected, CD-fed mice and vehicle-treated, CD-fed mice. Significance assessed by DESeq2 with an adjusted p-value < 0.01.