Fig. 2.

Effect of ATV and ATV+SM treatment on the relative mRNA expression of Hmgcr (A), Abcg5 and Abcg8 (B) and Srebf-1 and Srebf-2 (C) in the liver of HHTg rats. Data are expressed as mean ± SEM; n=8/group. ** p<0.01 and *** p<0.001 denotes significant difference between the control vs. ATV treated groups, and ⁺⁺ p<0.01 denotes significant difference between ATV vs. ATV+SM treated groups. ATV – experimental group of rats treated with atorvastatin, ATV+SM – experimental group of rats treated with atorvastatin and silymarin. Hmgcr – 3-hydroxy-3-methylglutaryl-CoA reductase, Abcg5 and Abcg8 – genes for ATP-binding cassette (ABC) cholesterol transporters G5 and G8, Srebf-1 and Srebf-2 – genes for sterol regulatory element binding transcription factor 1 and 2.