Table 1.
Metabolic effects of ATV and ATV+SM treatment.
| Control | ATV | p1 | ATV+SM | p2 | |
|---|---|---|---|---|---|
| Body weight (g) | 409 ± 7 | 420 ± 7 | NS | 416 ± 8 | NS |
| Relative weight of epididymal fat (g/100 g body weight) | 1.50 ± 0.09 | 1.74 ± 0.08 | NS | 1.44 ± 0.08 | <0.05 |
| TG (mmol/l) | 4.29 ± 0.21 | 2.30 ± 0.11 | <0.001 | 1.51 ± 0.09 | <0.001 |
| NEFA (mmol/l) | 0.69 ± 0.05 | 0.79 ± 0.05 | NS | 0.63 ± 0.03 | NS |
| Cholesterol (mmol/l) | 1.77 ± 0.04 | 1.85 ± 0.02 | NS | 1.85 ± 0.05 | NS |
| HDL-cholesterol (mmol/l) | 1.01 ± 0.04 | 1.21 ± 0.03 | <0.01 | 1.24 ± 0.05 | NS |
| Insulin (nmol/l) | 0.21 ± 0.03 | 0.32 ± 0.03 | <0.05 | 0.16 ± 0.02 | <0.01 |
| Non-fasting glucose (mmol/l) | 8.86 ± 0.17 | 9.50 ± 0.16 | <0.05 | 9.80 ± 0.13 | NS |
| AUC 0–120 min (mmol/l/2 h) | 729 ± 17 | 739 ± 7 | NS | 678 ± 18 | <0.05 |
| Creatine kinase (μkat/l) | 3.85 ± 0.28 | 3.11 ± 0.32 | NS | 3.48 ± 0.25 | NS |
Data are expressed as mean ± SEM; n=8/group. p1 denotes significant difference between the control vs. ATV treated groups, p2 denotes significant difference between ATV vs. ATV+SM treated groups, NS – not significant difference. ATV – experimental group of rats treated with atorvastatin, ATV+SM – experimental group of rats treated with atorvastatin and silymarin, TG – triglycerides, NEFA – nonesterified fatty acids, AUC0–120 min – the area under the curve during the oral glucose tolerance test.