Table 3.
Effect of ATV and ATV+SM treatment on plasma inflammation parameters.
| Control | ATV | p1 | ATV+SM | p2 | |
|---|---|---|---|---|---|
| hsCRP (mg/ml) | 0.83 ± 0.05 | 1.07 ± 0.06 | <0.01 | 0.87 ± 0.04 | <0.05 |
| MCP-1 (pg/ml) | 3863 ± 308 | 4352 ± 342 | NS | 4745 ± 314 | NS |
| IL-6 (pg/ml) | 97.4 ± 4.3 | 93.7 ± 6.1 | NS | 72.8 ± 3.9 | <0.05 |
Data are expressed as mean ± SEM; n=8/group. p1 denotes significant difference between the control vs. ATV treated groups, p2 denotes significant difference between ATV vs. ATV+SM treated groups, NS – not significant difference. ATV – experimental group of rats treated with atorvastatin, ATV+SM – experimental group of rats treated with atorvastatin and silymarin, hsCRP – high sensitivity C-reactive protein, MCP-1 – monocyte chemoattractant protein 1, IL-6 – interleukin 6.