Table 1.
Histopathological findings in kidneys from 3 groups.
Organ Findings | SD rat | SDT fatty rat | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||
Control | Dapagliflozin 1 mg/kg | ||||||||||||||||||
| |||||||||||||||||||
Animal number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | |
Glomerulus | |||||||||||||||||||
Increase, mesangial matrix | − | − | − | − | − | − | + | + | + | + | + | ± | + | ± | + | ± | + | + | |
Tubules | |||||||||||||||||||
Degeneration/regeneration | − | − | − | − | − | − | 2+ | 2+ | 2+ | 2+ | 2+ | + | + | ± | 2+ | + | ± | 2+ | |
Dilatation | − | − | − | − | − | − | 2+ | 2+ | 2+ | 2+ | 2+ | + | + | + | 2+ | + | + | + | |
Hyaline cast | − | − | − | − | − | − | + | + | ± | + | + | ± | ± | + | + | ± | ± | + | |
Armanni-Ebstein lesion | − | − | − | − | − | − | − | + | + | + | + | ± | − | − | − | − | − | − | |
Mineralization | − | − | − | − | − | − | + | ± | 2+ | + | + | + | ± | + | ± | + | + | + | |
Interstitial | |||||||||||||||||||
Infiltration, inflammatory cells | − | − | − | − | − | − | ± | ± | ± | + | + | − | ± | ± | + | ± | ± | ± | |
Fibrosis | − | − | − | − | − | − | ± | − | − | − | − | − | ± | − | − | − | − | − |
−: negative; ±: very slight; +: slight; 2+: moderate; 3+: severe.