Supplementary Table 1.
Fatty acid composition of lipid classes in plasma in Crohn’s disease (CD) as compared with controls.
| Fatty acid a | Phospholipids | Triacylglycerols | Cholesteryl esters | |||
|---|---|---|---|---|---|---|
| Controls | CD | Controls | CD | Controls | CD | |
| 14:0 | 0.28 [0.24–0.31] | 0.17 [0.11–0.22]*** | 2.1 [1.53–2.42] | 1.02 [0.72–1.47]** | 0.58 [0.51–0.70] | 0.42 [0.36–0.57] |
| 16:0 | 31.56 [30.69–33.03] | 29.54 [27.06–30.35]** | 28.18 [26.95–29.11] | 25.71 [24.11–27.50] | 11.41 [10.62–11.76] | 12.31 [10.92–13.60] |
| 16:1n−9 | 0.11 [0.11–0.14] | 0.12 [0.10–0.13] | 0.79 [0.75–0.95] | 0.61 [0.51–0.64]*** | 0.53 [0.41–0.55] | 0.47 [0.40–0.51] |
| 16:1n−7 | 0.47 [0.43–0.64] | 0.46 [0.40–0.60] | 3.25 [3.00–3.48] | 2.88 [2.24–3.22]* | 2.36 [2.10–2.92] | 2.78 [2.04–3.31] |
| 18:0 | 15.99 [14.83–17.49] | 14.24 [13.63–15.04]* | 3.08 [2.74–3.52] | 3.34 [2.64–4.15] | 0.88 [0.72–1.24] | 0.74 [0.62–0.83] |
| 18:1n−9 | 12.12 [11.6–13.51] | 11.17 [10.47–11.94]* | 41.31 [39.9–43.24] | 42.86 [40.58–44.39] | 21.08 [20.32–21.82] | 22.82 [20.07–26.55] |
| 18:1n−7 | 1.51 [1.31–1.75] | 1.84 [1.70–2.03]* | 2.26 [2.09–2.55] | 2.56 [2.33–2.73] | 0.83 [0.78–0.92] | 1.51 [1.29–1.84]*** |
| 18:2n−6 | 24.00 [21.50–24.56] | 21.18 [19.63–22.75]* | 15.48 [13.96–16.99] | 16.06 [13.42–18.01] | 55.77 [53.06–56.62] | 51.41 [49.26–54.13]** |
| 18:3n−6 | 0.09 [0.06–0.10] | 0.11 [0.08–0.17] | 0.26 [0.20–0.31] | 0.23 [0.16–0.35] | 0.89 [0.43–0.97] | 0.52 [0.35–0.70] |
| 18:3n−3 | 0.19 [0.12–0.25] | 0.20 [0.15–0.28] | 0.86 [0.76–0.92] | 0.69 [0.50–0.89] | 0.53 [0.46–0.78] | 0.45 [0.32–0.64] |
| 20:2n−6 | 1.11 [0.82–1.26] | 0.34 [0.27–0.45]*** | 0.42 [0.37–0.50] | 0.15 [0.12–0.21]*** | 0.09 [0.07–0.10] | 0.06 [0–0.11] |
| 20:3n−6 | 3.09 [2.88–3.36] | 3.18 [2.71–3.74] | 0.29 [0.26–0.31] | 0.26 [0.21–0.32] | 0.62 [0.56–0.69] | 0.79 [0.66–1.09]*** |
| 20:4n−6 | 8.19 [6.82–8.56] | 12.19 [10.47–13.27]*** | 0.49 [0.39–0.58] | 1.52 [0.98–1.87]*** | 3.54 [3.02–4.94] | 5.12 [3.12–7.75] |
| 20:5n−3 | 0.25 [0.15–0.35] | 0.58 [0.43–0.71]*** | 0.04 [0.03–0.05] | 0.11 [0.07–0.17]*** | 0.13 [0.07–0.18] | 0.10 [0.05–0.27] |
| 22:4n−6 | 0.17 [0.14–0.19] | 0.43 [0.33–0.50]*** | 0.04 [0.04–0.05] | 0.18 [0.14–0.22]*** | 0.01 [0.01–0.02] | 0.01 [0–0.02] |
| 22:5n−6 | 0.09 [0.07–0.11] | 0.32 [0.25–0.37]*** | 0.02 [0.01–0.02] | 0.12 [0.08–0.17]*** | 0.01 [0–0.01] | 0.01 [0–0.02] |
| 22:5n−3 | 0.31 [0.22–0.36] | 0.83 [0.73–1.00]*** | 0.04 [0.03–0.04] | 0.27 [0.21–0.33]*** | 0.01 [0.01–0.03] | 0.01 [0–0.04] |
| 22:6n−3 | 0.67 [0.51–0.72] | 2.78 [2.47–3.50]*** | 0.03 [0.02–0.03] | 0.34 [0.18–0.40]*** | 0.06 [0.05–0.09] | 0.02 [0–0.06] |
| ∑satur | 48.55 [48.05–49.19] | 43.43 [42.25–44.25]*** | 32.75 [31.6–34.73] | 30.12 [27.95–32.01] | 13.08 [12.26–13.33] | 13.44 [11.86–15.06] |
| ∑mono | 14.68 [13.96–16.29] | 13.69 [12.96–14.61] | 48.64 [46.96–50.56] | 48.67 [46.02–51.51] | 24.83 [23.65–25.65] | 27.53 [23.97–30.77] |
| ∑n−6 | 35.92 [33.28–36.59] | 38.42 [35.16–39.15] | 17.15 [15.65–18.63] | 18.66 [15.26–21.27] | 61.17 [60.25–63.47] | 56.96 [54.28–63.07] |
| ∑n−3 | 1.30 [1.23–1.68] | 4.46 [4.17–5.50]*** | 0.96 [0.86–1.06] | 1.36 [1.13–1.80]*** | 0.88 [0.61–1.05] | 0.67 [0.44–0.95] |
| ∑n−6/∑n−3 | 25.54 [20.94–28.52] | 8.43 [6.96–9.61]*** | 15.82 [14.33–22.38] | 13.41 [10.60–15.10]** | 71.48 [56.47–99.90] | 94.24 [64.49–129.6] |
∑ – sum, values – are expressed as mean (25th–75th percentile) (mol%), t-test:
*
p<0.05,
*
p<0.01,
**
p<0.001,
a
– shorthand notation of fatty acids – number before colon=number of double bonds; number after n=number of carbon atoms from the methyl end of the chain to the nearest double bond.
CD – Crohn’s disease.