Table 3. Comparison of the performances of the final RF and SVM models and other recent models on the external validation set.

Models	Accuracy %	Sensitivity %	Specificity %	MCC %
CYPlebrity	75.49	70.91	82.58	52.23
ADMETlab	79.57	70.81	93.01	62.69
RF 36 MOE + 7 IE	84.33	89.97	78.69	69.45
SVM 36 MOE + 7 IE	83.35	89.87	76.83	67.72