Figure 4.
RBD-OMV vaccination prevented loss of body mass after challenge with intranasal SARS-CoV-2, but did not affect body temperature or burrowing behavior. A) Syrian golden hamsters (4 males and 4 females per treatment group) were vaccinated on days 0, 14, and 28 with RBD-OMVs, control OMVs, or mock solution. Hamsters were challenged with 107 infectious units of SARS-CoV-2 on day 44. B-C) Body temperature was monitored via a subdermal chip weekly before and daily after virus challenge. D-E) Body mass was monitored weekly before and daily after virus challenge F-G) Mass on days 1–4 post-challenge was measured relative to body mass on day 42. For each day post-challenge, differences in mass loss between groups were tested by one-way ANOVA with Tukey’s post-hoc test, n = 4, * p < 0.05.