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. 2022 Jan 7;17(8):1785–1794. doi: 10.4103/1673-5374.332151

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Copyright: © Neural Regeneration Research

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Both the medium and high dose treatments partially restore the mRNA levels of genes coding ion channels and neurotransmitter receptors at the lesion site.

Real-time PCR analysis of the dosage effect of the human umbilical cord mesenchymal stem cell treatment on the repression of 40 ion channels and neurotransmitter receptors. Intact: Normal rat; SCI-7d: subacute SCI; PBS: phosphate-buffered saline; Low: low dose (0.25 × 10⁶ cells/kg); Medium: medium dose (1 × 10⁶ cells/kg); High: high dose (4 × 10⁶ cells/kg). Data are presented as mean ± SEM; n ≥ 3/group; n.s.: not significant; *P < 0.05, **P < 0.01, ***P < 0.001 (one-way analysis of variance).