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. 2022 Feb 7;11:e76818. doi: 10.7554/eLife.76818

Figure 1. Compartment-specific regulation of mRNA translation by FMRP in neurons.

Figure 1.

Hale et al. found that the mRNA binding protein FMRP plays an expanded role in regulating protein synthesis in hippocampal CA1 neurons (left). In the cell body (top inset), FMRP (green circle) binds and blocks the translation of synaptic (magenta) and chromatin regulator mRNA (blue and gold). Without FMRP, the stability and/or translation of its target mRNA in the cell body is altered. In the dendrite (bottom inset), FMRP represses the translation of synaptic regulator mRNA, consistent with the role of FMRP to modulate protein synthesis. This suggests that FMRP can interact with different populations of mRNA within subcellular compartments to both reversibly repress translation and regulate the availability of mRNA for protein synthesis.