Table 2.
Gamitrinib (5 mg/kg IV) PK in Sprague-Dawley rats
| PK Parameters | Unit | Rat 1 | Rat 2 | Rat 3 | Mean | SD | CV (%) |
|---|---|---|---|---|---|---|---|
| t1/2 | h | 11.623 | 11.107 | 14.022 | 12.250 | 1.555 | 12.7 |
| Cmax | ng/mL | 1153.712 | 829.668 | 1544.041 | 1175.807 | 357.699 | 30.4 |
| CL | mL/min/kg | 79.233 | 87.035 | 90.700 | 85.656 | 5.856 | 6.8 |
| MRT | h | 5.539 | 5.411 | 5.524 | 5.492 | 0.0702 | 1.3 |
| Vz | L/Kg | 79.715 | 83.678 | 110.085 | 91.159 | 16.509 | 18.1 |
| Vss | L/Kg | 58.230 | 60.052 | 78.131 | 65.471 | 11.001 | 16.8 |
| AUClast | h∙ng/mL | 851.441 | 789.045 | 709.112 | 783.199 | 71.344 | 9.1 |
| AUCINF | h∙ng/mL | 1051.752 | 957.472 | 918.784 | 976.002 | 68.394 | 7.0 |
AUCINF; area under concentration vs. time curve from time 0 to infinity; AUClast, area under concentration vs. time curve from time 0 to last quantifiable concentration; Cmax, maximum-observed concentration; CL, clearance; MRT, mean residence time; t1/2, terminal half-life; Vz, apparent volume of distribution; Vss, volume of distribution at steady-state.