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. 2021 Oct 7;122(2):196–207. doi: 10.1055/a-1663-8208

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

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Fig. 2 — FXIIa inhibition attenuated the development of stable atherosclerosis. ApoE ^−/− mice were placed on an HFD for 8 weeks to develop stable atherosclerosis. ( A ) H&E was used to morphologically assess plaque size ( p = 0.0031), ( B ) necrotic core area ( p = 0.0489), and ( C ) the collagen content ( p = 0.0169) in stable plaques of the aortic sinus, as compared with the BM4 control–treated animals (BM4 n = 6; 3F7 n = 5). Values are mean ± SD. Scale bars = 200 µm. Assays were assessed using unpaired Student's t -tests. Interrupted lines indicate total lesion area used for collagen content analysis. Representative images show one valve of the aortic sinus only. All valves were included in the analysis. H&E, hematoxylin and eosin; HFD, high-fat diet; SD, standard deviation.