Trends in the prevalence of sepsis and inhospital mortality of acute myocardial infarction complicated by cardiogenic shock (AMI-CS) admissions. A, Unadjusted temporal trends in the prevalence of AMI-CS admissions with concurrent sepsis stratified by type of AMI (p < 0.001 for trend over time). B, Adjusted odds ratio for prevalence of sepsis in ST-segment elevation myocardial infarction (STEMI)-CS and non-ST segment elevation myocardial infarction (NSTEMI)-CS admissions (with 2000 as the referent)*; p < 0.001 for trend over time. C, Unadjusted inhospital mortality in AMI-CS admissions stratified by the presence of sepsis and type of AMI (p < 0.001 for trend over time). D, Adjusted odds ratio for inhospital mortality by year (2000 as the referent) among AMI-CS with or without presence of sepsis, further stratified based on type of AMI**; p < 0.001 for trend over time. *Adjusted for age, sex, race, comorbidity, primary payer, income status, hospital region, hospital location and teaching status, and hospital bed size. **Adjusted for age, sex, race, income status, comorbidity, primary payer, hospital region, hospital location, teaching status, hospital bed size, acute organ failure, atrial fibrillation, atrial flutter, cardiac arrest, coronary angiography, percutaneous coronary intervention, coronary artery bypass grafting, pulmonary artery catheterization, mechanical circulatory support, invasive and noninvasive mechanical ventilation, and acute hemodialysis (p < 0.001 for trend over time).