Figure 2.

SARS-CoV-2 antibody responses and specific memory B cells in vaccinated HCWs

(A) Anti-Trimeric Spike-specific IgG, (B) total anti-RBD antibody levels, (C) percentage of Spike-specific MBCs, and (D) frequency of RBD-specific cells, identified inside the total Spike-positive MBCs, measured at different time points in vaccinated HCWs: before vaccine administration (T0), 7 days (1w), 3 (3mo), 6 (6mo), and 9 (9mo) months after the second dose (n = 34). (E) Simple linear regression models for Spike-specific MBCs and time (red line), and for anti-Trimeric Spike-specific IgG and time (blue line). Antibody titer is shown on a log₁₀ scale. Medians are indicated, and statistical significance was determined using Wilcoxon matched pairs signed rank test. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001.