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. Author manuscript; available in PMC: 2022 Jun 23.
Published in final edited form as: Chem Rev. 2021 Apr 6;121(12):7178–7248. doi: 10.1021/acs.chemrev.0c01108

Figure 5. Structures of clickable probes for protein S-palmitoylation.

Figure 5.

The native structures of palmitic acid and palmitoyl-CoA along with their azide- and alkyne-modified analogues are shown. Varying chain lengths can serve as surrogate for this lipid modification and hence can be generalized as S-acylation. The presence of a diazirine moiety in Alk-Dzn-C18 allows for a photocrosslinking strategy that enables identification of proteins that interact with fatty acylated proteins through the lipid modification.