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Effect of IONIS-FXIRx 200 mg and 300 mg on FXI activity compared with placebo during the 78-day treatment period and subsequent 85-day washout period. Points represent mean; whiskers represent SEM (intent-to-treat population). Red arrowheads indicate dosing day. FXI, factor XI; LLN, lower limit of normal; ULN, upper limit of normal.
