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. 2021 Nov 3;57(2):191–197. doi: 10.1038/s41409-021-01512-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — In total, ten patients (n = 10) dropped out of the enrolled study sample (n = 182; IC = 92; ICD = 90) related to the primary outcome (i) [n = 172; IC = 88; ICD = 84]. Two patients (n = 2; 1 in each intervention arm) did not continue the study due to fatal outcome related to disease progression. Eight patients (n = 8; 3 in the IC group and 5 in the ICD group) withdrew their consent to participate in the study. For the secondary outcome tolerability (ii–a) [n = 167; IC = 87; ICD = 80], 15 (n = 15; 5 in the IC group and 10 in the ICD group) patients were not able to pursue the assessment; for the secondary outcome patient-reported oral pain (ii–b) [n = 145; IC = 76; ICD = 69], 37 (n = 37; 16 in the IC group and 21 in the ICD group) did not submit the completed forms. IC, ice chips; ICD, intraoral cooling device.