Table 3.
Multivariable regression analysis for major bleeding complications
| Generalized estimating equations (group variable: hospital code) | Multivariable analysis |
|
|---|---|---|
| RR (95% CI) | P value | |
| Diabetes mellitus | 2.41 (2.00–2.90) | <0.001 |
| Age, yr | 1.04 (1.03–1.04) | <0.001 |
| Female, sex | 1.49 (1.27–1.76) | <0.001 |
| BMI (kg/m2) | See Figure 2 | |
| Main diagnosis | ||
| AKI or RPGN | 3.86 (3.17–4.71) | <0.001 |
| Nephrosis | 0.89 (0.70–1.14) | 0.35 |
| Others | 1 (base) | |
| Presence of CKD | 2.50 (2.11–2.97) | <0.001 |
| Hospital volume | ||
| 1–24/yr | 1 (base) | |
| 25–44/yr | 0.86 (0.71–1.05) | 0.15 |
| ≥45/yr | 0.90 (0.73–1.10) | 0.29 |
| Academic hospital | 1.41 (1.16–1.71) | 0.001 |
| Fiscal year period | 0.21 | |
| 2010–2015 | 1 (base) | |
| 2016–2017 | 0.90 (0.76–1.06) | |
| ADL | <0.001 | |
| Dependent | 2.57 (2.00–3.29) | |
| Independent | 1 (base) | |
| Corticosteroid use | 1.41 (1.05–1.89) | 0.022 |
| Immunosuppressant use | 1.13 (0.52–2.45) | 0.75 |
| Antithrombotic use | 1.14 (0.75–1.74) | 0.53 |
ADL, activities of daily living; AKI, acute kidney injury; BMI, body mass index; CKD, chronic kidney disease; RPGN, rapidly progressive glomerulonephritis; RR, relative risk.
BMI calculated as weight in kilograms divided by the square of height in meters.