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. 2021 Oct 1;181(2):783–788. doi: 10.1007/s00431-021-04270-1

Table 1.

Description of study population according to GMFCS classification as mild, moderate, and severe impairment groups

GMFCS Total
Mild Moderate Severe
Number of participants n = 6 n = 3 n = 63 N = 72
Mean (SD) age in months 14.5 (1.4) 11.7 (0.6) 14.1 (4.7) 13.9 (4.4)
Sex Female 3 (50.0%) 1 (33.3%) 29 (46.0%) 33 (45.8%)
Male 3 (50.0%) 2 (66.7%) 34 (54.0%) 39 (54.2%)
Microcephaly Yes 2 (33.3%) 0 51 (81.0%) 53 (73.6%)
No 4 (66.7%) 3 (100%) 12 (19.0%) 19 (26.4%)
Microcephaly severity Moderate 1 (50.0%) 0 16 (31.4%) 17 (32.1%)
Severe 1 (50.0%) 0 35 (68.6%) 36 (67.9%)

ZIKV detection

(RT-PCR)

Yes 4 (66.7%) 2 (66.7%) 25 (39.7%) 31 (43%)
No 2 (33.3%) 1 (33.3%) 38 (60.3%) 41 (57%)
Physical therapy Yes 4 (66.7%) 3 (100%) 56 (88.9%) 65 (87.5%)
No 2 (33.3%) 0 7 (11.1%) 9 (12.5%)
GMFCS levels

I = 0

II = 6

II = 3

IV = 42

V = 21

Mean (SD) GMFM 81.6 (5.9) 26.1 (7.0) 11.6 (3.6) 17.6 (20.2)

GMFCS, gross motor function classification system; RT-PCR, reverse transcription-polymerase chain reaction; ZIKV, Zika virus