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. 2022 Jan 25;8:741221. doi: 10.3389/fcvm.2021.741221

Figure 1.

Figure 1

Flow chart showing the enrolled study population and its allocation within the main experimental procedures. Of 86 patients with NSTEMI, 35 underwent OCT investigation, defining n = 16 IFC, and n = 19 RFC. Obtained PBMC from 80 NSTEMI, 27 patients with SA and 19 CTRL subjects enrolled were evaluated for CD31 expression by flow cytometry. Platelet CD31 was assessed by flow-cytometry on 53 NSTEMI, 36 patients with SA, and 8 CTRL subjects. Thrombus grade analysis was performed on the latter 53 patients with NSTEMI. For co-culture binding experiments, 20 NSTEMI and 6 SA were employed. Finally, 11 were engaged for CD31 ligation experiments; of those patients, 5 were investigated through confocal microscopy. CTRL, control subjects; IFC, intact fibrous cap; NSTEMI, non-ST-elevation myocardial infarction; PBMCs, peripheral blood mononuclear cells; PLTs, platelets; RFC, ruptured fibrous cap; and SA, stable angina patients (art images from http://smart.servier.com/ site).