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. 2022 Jan 25;13:785422. doi: 10.3389/fimmu.2022.785422

Figure 5.

Figure 5

Megasphaera sp.XA511 (M.sp.XA511) enhances the efficacy of PD-1 blockade in vivo. (A) Experiment design of the mouse study. 6-week-old SPF Balb/c mice bearing 4T1 tumors were administrated with Megasphaera sp. XA511 daily, Isotype or anti-PD-1 antibodies were administered to the animals on days 9, 12, 15 and 18 by intraperitoneal injection. (B) Tumour volumes were measured on day7, day9, day11, day14, day16, day18 and day21 after inoculation of tumour cells. Tumor size data were analysed and expressed as the mean ± standard deviation. The one-way ANOVA was used to determine whether there are any statistically significant differences between the means of PD1 combined with Megasphaera sp. XA511 and other groups. The black, red, green, and blue colour indicate Control, Megasphaera sp. XA511, antiPD1 and antiPD1 combined with Megasphaera sp. XA511group respectively. The asterisk indicates significant difference (*P < 0.05, **P < 0.01).