Table 5.
Comparison of clinical efficacy of DRPAs vs. placebo using number needed to treat for therapeutic response (NNT, 95% CI) in schizophrenia, acute mania (7), bipolar depression (71, 72), and major depression (70).
| Aripiprazole | Brexpiprazole | Cariprazine | |
|---|---|---|---|
| Schizophrenia—acute treatment | 8 (6, 13) | 7 (5, 12) | 10 (7, 18) |
| Schizophrenia—relapse prevention | 5* | 4* | 5* |
| Bipolar mania | 7 (5, 11) | n.s. | 5 (4, 18) |
| Bipolar depression | 45 (10, ∞) | – | 10 (7, 21) |
| Major depressive disorder | 9 (5, 24) | 16 (8, 52) | 16 (10, 34) |
*
based on a single study; n.s., no significant difference.